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Current Research Projects
- Methodology Development
Attracted by the unique properties of 1,2,3-triazole, our group developed a series of synthetic and functionalization methods of 1,2,3-triazoles. With these practical synthetic methods, we were able to explore several metal complexes utilizing triazole as the ligand, such as Au, Rh, Pd and Ir, which showed different reactivities compared with conventional ligands. We are now focusing on new methodology development based on triazole-metal catalysts and the “why” behind the “how”.
- Asymmetric Catalysis
Ligand design based on 1,2,3-triazole skeleton for asymmetric catalysis is another interest of our group. Taking advantage of the unique binding properties and easy synthesis of various triazole derivatives, it is promising that we will develop some efficient chiral ligands.
- New Material Development
Azaborines are interesting new materials since the B-N bond is isoelectronic with a C-C double bond. Based on the excellent stability and chemoselectivity of triazole-gold catalyst, new synthetic method for aza-borane was achieved in our group and will be further developed.
By cooperation with Prof. Shengqian Ma, various triazole-based MOF material were synthesized and characterized. Along with that, we will also develop MOF catalysts based on triazole-skeleton.
- Bioorganic Chemistry
Another inspiring feature of 1,2,3-triazole is the excellent biocompatibility. With that in mind, we developed a series of triazole derivatives and applied them sucessfully as fluorophores or anti-cancer drugs. We are also interested in target-oriented synthesis and application of these molecules in vivo.
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